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Background

Research Focus

Stem cell engineering, bioinformatics, proteomics, environmental engineering and food science.

One research focus is the fundamental and transformative study of stem-cell differentiation and interplay between cells and their microenvironments with a goal of generating clinically relevant tissues/organoids for disease modeling, drug discovery and cell-based therapy. The lab aims to understand cues and signaling critical for engineering functional organoids and to promote the maturation of tissues/organoids derived from stem cells.

Another focus is to mitigate global warming and climate change caused by environmental pollution. Food waste is an inevitable global problem. According to an Environmental Protection Agency (EPA) report, food waste represents the largest component of US landfills, accounting for a quarter of the solid waste. Methane exhausted from the landfilled food waste is linked to global climate change and extreme weather. We aim to apply modern biotechnology and bioengineering approaches to convert food waste into ecofriendly value-added industrial/medical products.

Tissue Biomolecular Lab

Selected Recent Publications

Complete List of Publications:

Walsh, C. and Jin, S. “Induced Pluripotent Stem Cells and CRISPR-Cas9 Innovations for Treating Alpha-1 Antitrypsin Deficiency and Glycogen Storage Diseases”. Cells. (2024) 13 (12), 1052.

Li, M., Freeman, S., Franco-Barraza, J., Kim, A., Jin, S., Cukierman, E., and Ye, K. “A Bioprinted Sea-and-Island Multicellular Model for Dissecting Human Pancreatic Tumor-Stroma Reciprocity and Adaptive Metabolism”. Biomaterials. 310, (2024), 122631, May 31, 2024.

Mahabeer, G. and Jin, S. “Upcycling Food Waste into Biomaterials Applicable to Medical Products”. Sustainability. May 2024, 16, 4473.

Huang, H., Karanth, SS., Guan, Y., Freeman, S.R., Soron, R., Godovich, S.D., Guan, J., Ye, K. and Jin, S. “Oxygenated Scaffolds for Pancreatic Endocrine Differentiation from iPSCs”. Advanced Healthcare Materials. 13(3), (2024) (The Journal’s inside front cover.)

Huang, H., Karanth, SS., Guan, Y., Freeman, S., Soron, R., Godovich, DS., Guan, JJ., Ye, K. and Jin, S. “Oxygenated Scaffolds for Pancreatic Endocrine Differentiation from iPSCs”. Advanced Healthcare Materials. (2023) Oct 26:e2302275.

Heaton, E. Hu, M., Liu, T., Huang, H., Tan, YF., Ye, K. and Jin, S. “Extracellular Matrix-Derived Peptide Stimulates the Generation of Endocrine Progenitors and Islet Organoids from iPSCs”. Journal of Tissue Engineering. (2023), 14, 1-16. . July 8, 2023

Ogi, A.D. and Jin, S. “Transcriptome-Powered Pluripotent Stem Cell Differentiation for Regenerative Medicine”. Cells. (2023), 12, 1442. . May 22, 2023.

Heaton, E. and Jin, S. “Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment”. Translational Research. (Invited review) July 21, 2022 DOI:

Freeman, S., Calabro, S., Williams, R., Jin, S., and Ye, K. “Bioink Formulation and Machine Learning-Empowered Bioprinting Optimization”. Front. Bioeng. Biotechnol., 13 June 2022, .

Moffat, D., Ye, K., and Jin, S., “Decellularization for the Retention of Tissue Niches”. Journal of Tissue Engineering. 13: 1–29; May 21, 2022. 

Freeman, S., Kibrler, K., Lipsky, Z., Jin, S., German, G., and Ye, K. “Systematic Evaluating and Modeling of SARS-CoV-2 UVC Disinfection”. Sci Rep. 12, 5869 (2022). .

Yefroyev, D.A., and Jin, S. (2022) “Induced Pluripotent Stem Cells for Treatment of Alzheimer’s and Parkinson’s Diseases”. Biomedicines. 10(2), 208; .

Hu, M., Bi, H., Moffat, D., Blystone, M., DeCostanza, P., Alayi, T., Ye, K., Hathout, Y., and Jin, S. (2021) “Proteomic and Bioinformatic Analysis of Decellularized Pancreatic Extracellular Matrices”. Molecules. 26(21), 6740;

Karanth, SK., Sun, S., Bi, H., Ye, K., and Jin, S. (2021) “Angiopoietins stimulate pancreatic islet development from stem cells.” Sci Rep. 2021, Jun 30;11(1):13558.

Huang H., Bader, T., and Jin, S. (2020) “Signaling Molecules Regulating Pancreatic Endocrine Development from Pluripotent Stem Cell Differentiation.” Int J Mol Sci. 2020, 21(16), 5867;

Bi, H., Karanth, S., Ye, K., Stein, R., and Jin, S. (2020) “Decellularized Tissue Matrix Enhances Self-Assembly of Islet Organoids from Pluripotent Stem Cell Differentiation.” ACS Biomaterials Science & Engineering. May 21, 2020,

Bi, H., Ye, K., and Jin, S. (2020) “Proteomic analysis of decellularized pancreatic matrix identifies collagen V as a critical regulator for islet organogenesis from human pluripotent stem cells.” Biomaterials. 233: 119673.

Jayaraman, S., Bi, H., Sen, P., Everhart, B., Jin, S., and Ye, K. “Inducing Tumor Suppressive Microenvironments through Genome Edited CD47−/− Syngeneic Cell Vaccination.” Sci Rep 9, 20057 (2019) doi:10.1038/s41598-019-56370-6

Freeman, S., Ramos, R., Chando, PA., Zhou, L., Reeser, K., Jin, S., Soman, P., and Ye, K. (2019) “A bioink blend for rotary 3D bioprinting tissue engineered small-diameter vascular constructs.” Acta Biomaterialia, 95, 152-164.

Hai, N., Shin, D.W., Bi, H., Ye, K., and Jin, S. (2018) ^“Mechanistic analysis of physicochemical cues in promoting human pluripotent stem cell self-renewal and metabolism.” Int J Mol Sci. 2018 Nov 4;19(11), doi:10.3390/ijms19113459

Xia, Z., Jin,S., and Ye,K. (2018) Tissue and Organ 3D Bioprinting, SLAS Technol. Feb 1:2472630318760515. doi: 10.1177/2472630318760515.

Wang W., Jin,S., and Ye,K. (2017) Development of Islet Organoids from H9 Human Embryonic Stem Cells in Biomimetic 3D Scaffolds. Stem Cells Dev. 2017 Jan 11. doi: 10.1089/scd.2016.0115.

Lei, H., Jin, S., Karlsson, E., Schultz-Cherry, S., and Ye, K. (2016). Yeast Surface Displayed H5N1 Avian Influenza Vaccines. Journal of Immunology Research 2016: 4131324. doi: 10.1155/2016/4131324.

McReynolds, J., Wen, Y., Li, X., Guan, J., and Jin, S. (2016) Modeling Spatial Distribution of Oxygen in 3D Culture of Islet beta-Cells. Biotechnology Progress. 2016 Nov 1. doi: 10.1002/btpr.2395.

Zhou C., Jin, S., and Willing, R. (2016) Simulation of extracellular matrix remodeling by fibroblast cells in soft three-dimensional bioresorbable scaffolds. Biomech Model Mechanobiol. 15(6):1685-1698

Leach, J.C.; Wang, A.; Ye, K.; Jin, S. (2016) A RNA-DNA Hybrid Aptamer for Nanoparticle-Based Prostate Tumor Targeted Drug Delivery. Int. J. Mol. Sci.17(3) 380. doi: 10.3390/ijms17030380

Wang, L., Wang, R., Kong, BW., Jin, S., Ye, K., Fang, W. and Li, Y. (2015) B cells using a calcium signaling for specific and rapid detection of Escherichia coli O157:H7. Scientific Reports Jun 2; 5:10598. doi: 10.1038/srep10598

Enam, S. and Jin, S. (2015) Substrates for clinical applicability of stem cells. World J. Stem Cells. 7(2): 243-252

Wen, Y. and Jin, S. (2014) Production of neural stem cells from human pluripotent stem cells. J. Biotechnology 188C:122-129

Jin, S. (2014) Regeneration of Islet β-cells from stem cells and progenitors. J. Stem Cell Research & Transplantation 1(1):4

Alismail, H. and Jin, S. (2014) Microenvironmental stimuli for proliferation of functional islet β-cells. Cell & Bioscience 4:12

Zaki, S. and Jin, S. (2014) Targeted therapies against gliomas. J. of Tumor 2(3): 99-107

Jin, S. (2013) Therapeutic potential of natural catechins in antiviral activity. JSM Biotechnology & Biomedical Engineering 1: 1002

Jin, S., and Ye, K. (2013) Targeted drug delivery for breast cancer treatment. Recent patents on anti-cancer drug discovery, 8(2):143-153.

Earls, J., Jin, S., and Ye, K. (2013) Mechanobiology of human pluripotent stem cells. Tissue Engineering, Part B. April 16.

Yao, H., Jin, S. (2012) Enhancement of probe signal for screening of HIV-1 protease inhibitors in living cells. Sensors 12 (12): 16759-16770.

Jin, S., Yao, H., Weber, J.L., Melkoumian, Z.K., and Ye, K. (2012) A synthetic, xeno-free peptide surface for expansion and directed differentiation of human induced pluripotent stem cells. PLoS ONE. 7(11): e50880. doi:10.1371/journal.pone.0050880

Jin, S., Yao, H., Krisanarungson, P., Haukas, A. and Ye, K. (2012) Porous membrane substrates offer better niches to enhance the Wnt signaling and promote human embryonic stem cell growth and differentiation, Tissue Engineering: Part A. 18(13-14): 1419-1430.

Veetil, JV, Jin, S., Ye, K. (2012) Fluorescence lifetime imaging microscopy of intracellular glucose dynamics. Journal of Diabetes Science and Technology. 6(6):1276–1285.

Ye, K. and Jin, S. (2011) Directed differentiation of human embryonic stem and patient-specific stem cells into lineage-specific cells for regenerative medicine, Humana Press, USA. ISBN 13: 9781617792663, ISBN 10: 1617792667.

Zhu, Y., Dong, Z., Wejinya, U.C., Jin, S., and Ye, K. (2011) Determination of mechanical properties of soft tissue scaffolds by atomic force microscopy nanoindentation. J. Biomechanics. 44, 2356-2361.

Jin, S, Veetil, JV, Garrett, JR., Ye, K. (2011) Construction of a panel of glucose indicator proteins for continuous glucose monitoring. Biosensors and Bioelectronics. 26, 3427-3431.

Jin, S, Ellis, E., Veetil. JV, Yao, H. and Ye. K. (2011) Visualization of human immunodeficiency virus protease inhibition using a novel Förster resonance energy transfer molecular probe. Biotechnol. Prog. 27 (4), 1107-1114.

Veetil, V.J., Jin, S. and Ye, K. (2010) A Glucose Sensor Protein for Continuous Glucose Monitoring. Biosensors and Bioelectronics. 26, 1650–1655.

Zhang, B., Sun, C., Jin, S., Cascio, M., and Montelaro, R.C. (2008) Mapping of equine lentivirus receptor 1 residues critical for EIAV envelope binding. J. Virol. 82: 1204-1213.

Garett, J.R., Wu, X., Sha, J. and Ye, K. (2008) pH-insensitive Glucose Indicators. Biotechnol. Prog. 24, 1085-1089

Jin, S., Ye, K., (2007) Nanoparticles-mediated drug delivery and gene therapy. Biotechnol. Progress. 23: 32-41.

Ye, K., Jin, S., (2006) Potent and Specific Inhibition of Retroviral Replication by Coexpression of Multiple siRNAs Directed Against Different Regions of Viral Genomes. Biotechnol. Progress. 22: 45-52.

Jin, S., Weisz, O., and Montelaro, R. C. (2005) pH-dependent endocytic entry by equine infectious anemia virus infection. J. Virol. 79(23):14489-97.

Zhang, B., Jin, S., Jin, J., Li, F., and Montelaro, R. C. (2005) A tumor necrosis factor receptor family protein serves as a cellular receptor for the macrophage-tropic equine lentivirus. Proc Natl Acad Sci U S A 102(28): 9918-9923.

Jin, S., Chen, C., and Montelaro, R. C. (2005) Equine infectious anemia virus Gag p9 function in early steps of virus infection and provirus production. J. Virol. 79(14): 8793-8801.

Education

• BS, MS, East China University of Science and Technology
• PhD, Kyushu University Institute of Technology

Research Interests

• Stem-cell engineering
• Proteomics and bioinformatics
• Cell signaling
  
• Environmental engineering

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